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Rabbit Anti-Rat Pyridoxal Kinase (PDXK) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat pyridoxal kinase. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of rat pyridoxal kinase.
Specifications
Target Information
Rat pyridoxal kinase catalyzes the ATP-dependent phosphorylation of vitamin B6 forms, converting pyridoxal, pyridoxine and pyridoxamine into their 5'-phosphate esters. This reaction targets the active coenzyme pool, driving over 140 PLP-dependent enzymes involved in amino-acid, neurotransmitter and heme synthesis. The kinase is cytosolic and highly expressed in liver, brain and erythrocytes, where rapid PLP turnover occurs. Its unique ATP-grasp fold offers a conserved, catalytic-face epitope ideal for antibody generation; anti-pyridoxal-kinase immunoreagents therefore detect B6-metabolizing cells in situ without cross-reacting with other kinases or PLP-binding proteins.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.