Animal Immunocastration Vaccine Development

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Immunocastration utilizes the regulatory mechanisms of an animal's immune system to reduce an animal's reproductive capacity. This method is designed to block the hypothalamic-pituitary-gonadal (HPG) axis to reduce pituitary hormone secretion, sex hormone synthesis, sexual behavior, and testicular growth in order to achieve a denuding effect. Traditional means of castration cause pain and higher risk to animals, and with BioVenic's commitment to promoting animal welfare, we utilize the power of the immune system to provide vaccine solutions for the management of animal reproduction.

Animal Immunocastration Vaccine Development Services

Target Screening

Target selection is important for immunocastration. Past studies have shown that immunodeficiency achieved through the use of reproductive hormones such as FSH, LH, or testosterone is not as effective and stable, possibly due to that the above targets are downstream of the HPG axis. BioVenic helps you to shift the target of immunocastration vaccines to the upstream of the HPG axis by using upstream targets such as GnRH hormones, GnRH genes and KISS-1 genes.

Fig.1 HPG axis of reproductive hormone secretion. (BioVenic Original)

Animal Immunocastration Vaccine Development Platforms

Based on immunogenic targets, including reproductive hormones and regulatory genes, BioVenic offers immunocastration vaccine development plaftorms based on gene immunocastration and hormone immunocastration.

Platforms	Description	Advantages	Relative Services
Hormone Immunocastration Vaccine	Targeting reproductive hormones in the HPG axis to reduce their concentrations.	Side effect free.	Carrier protein preparation Recombinant protein customization
Gene (DNA) Immunocastration Vaccine	Plasmids expressing antigenic protein genes are injected into animals, inducing the host immune system to produce specific antibodies that neutralize endogenous reproductive hormones.	Cost-effective. Easy to manufacture	Plasmid construction DNA purification

Safety and Effectiveness Assessment

The safety of immunocastration vaccines for livestock or companion animals is of paramount importance, and the effectiveness needs to be evaluated to achieve the purpose of immunocastration vaccines. BioVenic offers safety and efficacy assessment services to evaluate their effectiveness of vaccines using animal appearance, behavioral examinations, pathology tests, and serum antibody and testosterone tests.

Safety Assessment

Effectiveness Assessment

Applications of Immunocastration Vaccines

Immunocastration vaccines reduce animal's ability to reproduce by activating the immune system without the need for surgical intervention. The method offers multiple advantages, including non-invasiveness, reversibility, broad applicability, and excellent immunization results. BioVenic provides innovative solutions for reproduction control via immunocastration, leading to a more sustainable and healthy approach for animal management.

Our Advantages

Optimal Animal Models

Immunocastration is mainly for livestock and companion animals. BioVenic offers you with suitable animal models to make your animal immunocastration vaccine closer to the actual situation and improve the efficiency of the development process.

Diverse Technology Platform Offering

BioVenic offers a variety of technology platforms that give you the option to develop the type of animal immunocastration vaccine you want.

Rigorous Assessment Session

To validate the development of vaccines that effectively achieve immunocastration, BioVenic offers rigorous assessments, supporting your subsequent development and production efforts.

In the field of animal immunocastration vaccine development, BioVenic is resolute in delivering streamlined and effective solutions tailored to your specific requirements. Our team is poised to provide comprehensive animal immunocastration vaccine development information for livestock, companion animals, and more. If you are interested in our services, please feel free to contact us to delve deeper into our offerings, your pursuit of groundbreaking solutions will begin with this simple conversation.

References

Ahmed, Sohail, et al. "New trends in immunocastration and its potential to improve animal welfare: a mini review." Tropical Animal Health and Production 54.6 (2022): 369.
Fan-mei, Z. E. N. G., et al. "Recent advances in immunocastration in sheep and goat and its animal welfare benefits: A review." Journal of Integrative Agriculture 21.2 (2022): 299-309.