Combined Veterinary Vaccine Development

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Due to limited cross-protection between pathogen strains, and avoiding multiple injections in animals, combined veterinary vaccines are used for animal immunization. These aim to immunize against more than one disease or serotype of pathogens. BioVenic offers combined veterinary vaccine development services, drawing from extensive experience in the development of bacterial and viral veterinary vaccines, meeting your single-dose, multi-purpose needs.

Our Services

Target Discovery

The selection of target antigens is crucial for combined veterinary vaccine development. BioVenic, by delving into the molecular mechanisms of host-pathogen and pathogen-pathogen interactions, is committed to identifying potential antigens as candidates and targets for vaccine development. BioVenic offers comprehensive antigen discovery services, employing precise experimental design and integrated data analysis to identify antigens that have the potential to elicit robust and lasting immune responses within the animal host.

Genome Sequencing

Epitope Mapping

Antigen Identification

Formulation Development

In combined veterinary vaccines, the presence of multiple components often leads to interactions, causing a weakening or enhancement of individual component responses. BioVenic offers formulation development services to ensure that interactions, whether between antigens or antigens-adjuvants, in your combined veterinary vaccine do not compromise the safety and efficacy of the vaccine product.

Fig.1 Schematic structures of three types of phage-based vaccines ¹

Antigen Combination

As the active ingredient in the vaccine, the physical and chemical compatibility of antigen combination needs to be researched. BioVenic provides services for antigen compatibility studies.

Adjuvant Development

BioVenic provides choices for adding adjuvants to the formulation of combined veterinary vaccines. Adjuvants enhance the immunogenicity of vaccines, but interactions between antigens and adjuvants have different effects on the animal's response to vaccines, including adverse reactions and efficacy. BioVenic offers customized adjuvant development services, providing a variety of adjuvant combinations for selection.

Safety and Efficacy Assessments

The safety and efficacy of combined veterinary vaccines are typically demonstrated with vaccines containing the maximum number of components. BioVenic provides suitable animal models and relevant in vitro and in vivo tests for assessment, such as serological assays (ELISA), molecular assays (PCR), and flow cytometry, to assist you in completing the assessment process for combined veterinary vaccines.

In Vitro Assays

In Vivo Assays

Safety Assessment	Single, overdose, and repeat-dose safety studies.
	Reproductive, immune function, and interaction effect studies.
Efficacy Assessment	The minimum titer or potency of each component.
	From different batches.

Quality Control

BioVenic has implemented a series of stringent measures in quality control for combined veterinary vaccines to ensure compliance with regulations and relevant guidelines.

Control of Production Environment and Raw Materials

BioVenic provides a controlled production environment, including cleanrooms and aseptic equipment, to prevent any contaminants from entering the vaccine development process. Additionally, purity tests are conducted on antigens, adjuvants, and excipients used as components in the vaccine formulation to ensure the quality of raw materials.

Stability Testing

BioVenic offers stability testing services, including assessments at different time points and temperatures during storage and transportation processes, ensuring that your vaccine maintains its efficacy in diverse environmental conditions after the development phase.

Endotoxin Residue Testing

Consideration is also given to the impact of increasing the endotoxin load from pathogen combination, BioVenic offers endotoxin residue testing to prevent safety issues.

Why Choose Us?

Striving for excellence in the formulation of combined veterinary vaccines, we aim to enhance your vaccine's ability to combat a wider range of animal diseases while maintaining a high level of safety.
BioVenic provides comprehensive assessments to ensure the safety and efficacy of your combined veterinary vaccine.
Rigorous quality control is implemented to maintain batch consistency and stability.

Combined veterinary vaccines can help overcome key challenges in maintaining coverage by simplifying the vaccination process and reducing the number of injections required. However, developing combined veterinary vaccines while maintaining immunogenicity and safety presents certain technical challenges. BioVenic has established advanced technological platforms, which is poised to assist you in developing combined veterinary vaccines targeting specific pathogens. Please contact us for more information on the development of combined veterinary vaccines!

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