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Animal Blood & Plasma & Serum Metabolomics
Metabolomics-related Services for Animal Blood & Plasma & Serum
BioVenic provides metabolomic analysis of animal blood, plasma, and serum samples to uncover omics information related to animal physiological status and health, supporting research that aims to understand an animal's complete biochemical processes or specific metabolic pathways. Our platform covers the full workflow—standardized sample collection and preparation, high-throughput metabolite detection and quantification by NMR, HPLC-UV, LC-MS, GC-MS, and ICP-MS, and data acquisition, statistics, and bioinformatics analysis including univariate, multivariate, and cluster analysis. We support tailored, one-stop programs spanning biomarker identification and quantification, drug development and pharmacodynamics, disease diagnosis and monitoring, nutritional research, and environmental toxicology, delivering accurate metabolic data and detailed bioinformatics reports.
Fig.1 Schematic Diagram of Diversity of Metabolic Components in Mammalian Blood1,2.
Metabolomics-related Services for Animal Blood & Plasma & Serum
- Sample Collection and Preparation
The composition of animal blood changes all the time due to the dynamic regulation of metabolism. Standardized blood sample preparation procedures are crucial to prevent fluctuations in results caused by individual variations. BioVenic's blood sample collection and preparation services can ensure that unstable components in blood samples are not oxidized, polymerized, or degraded due to the influence of external factors. We further ensure the reproducibility and scientific nature of the experiment by optimizing the pre-processing process for sample detection.
- Metabolite Detection
BioVenic's blood sample metabolomics analysis service based on a variety of biochemical analysis methods and technology platforms can achieve high-throughput detection and identification of metabolites using a small number of samples. We identify and quantify the metabolites in the sample based on their chemical classification and quantity. Through the data obtained from the detection platform, which includes retention time, molecular mass, and other parameters, we identify and verify the structure of the metabolites in the biological sample with a comprehensive and detailed inspection report. BioVenic offers customized metabolomics detection and analysis solutions for animal blood samples to solve scientific problems in the process of screening differential metabolites and discovering new biochemical markers.
- Data Acquisition and Statistics
BioVenic launches data processing and statistical analysis services for the large and complex data sets generated by metabolomic analysis of biological samples using high-throughput instruments like GC-MS and LC-MS. We leverage our extensive experience in metabolomics data processing and utilize a wide range of algorithms and processes to analyze and process the information obtained through high-throughput detection for scientific research customers. All you need to do is provide instrument detection data sets of animal blood samples, and we make it easy for you to visualize the data.
- Bioinformatics Analysis
BioVenic has a strong background in biology and has accumulated a significant number of animal metabolomics analysis cases. With more accurate data collection, we perform comprehensive bioinformatics analysis and generate reports for all measurable analytes in test samples. BioVenic selects the focus of analysis through communication and customizes exclusive analysis directions to meet the specific needs of customers. Our animal metabolomics bioinformatics services support univariate analysis, multivariate analysis and metabolomic cluster analysis and other services.
Flow Chart of Animal Non-targeted Metabolomics Analysis Service
Applications of Animal Blood & Plasma & Serum Metabolomic Analysis
| Contents | Applications | |
| Metabolite identification and quantification | Identification and detection of biomarkers such as lipids, amino acids, sugars, nucleotides, etc. | Health monitoring, metabolic pathway analysis and reconstruction. |
| Drug development and pharmacodynamics | Assessing drug metabolic pathways, toxicity, and therapeutic efficacy. | New drug development and efficacy evaluation, individualized drug treatment, drug treatment plan customization. |
| Disease diagnosis and monitoring | Searching for early disease biomarkers. | Diagnose diseases in advance, monitor disease progression and treatment effects. |
| Physiological and health status research | Study of metabolic differences in animals under different physiological states, health conditions and living conditions. | Health monitoring, early detection of health problems, understanding of life course and aging process. |
| Nutritional research | Evaluating the effects of different dietary and nutritional interventions on metabolism. | Scientific feeding of farm animals, health monitoring, and diet plan customization. |
| Environmental Toxicology | Detection of metabolic changes in animals when exposed to environmental pollution and toxicants. | Monitoring of environmental health and ecosystem changes. |
Related Research
In a systematic review quantitatively summarizing the current status of livestock metabolomics across five major species (cattle, sheep, goats, horses, and pigs), the application of biofluid and tissue metabolomics for animal health assessment, disease diagnosis, and production trait characterization was comprehensively evaluated. The review analyzed 149 published metabolomics studies (1930–2015, meeting inclusion criteria) and found that milk (27%) and blood serum (25%) were the most frequently sampled biofluids, followed by urine (18%), blood plasma (15%), and rumen fluid (6%). Analytical platform preferences revealed that nuclear magnetic resonance (NMR) spectroscopy was used in 42% of studies, mass spectrometry (MS) alone in 32%, and combined NMR/MS in 22%. In cattle, metabolomics identified biomarkers for feed efficiency (such as amino acids and lipid species), metabolic diseases (ketosis: elevated β-hydroxybutyrate and non-esterified fatty acids; fatty liver: altered triglycerides and bile acids), and mastitis (milk metabolites like lactate and acute-phase biomarkers). In swine, metabolomics discriminated between phenotypes based on energy and amino acid profiles, as well as disease responses such as PRRSV infection. This work establishes livestock metabolomics as an emerging omics platform for precision animal agriculture, spanning applications in nutritional optimization, disease surveillance, and trait selection.
Fig. 2 Relative sensitivity of metabolomics platforms3
Why Choose Us?
Rich experience in processing various animal blood samples and identifying their metabolites.
Diversified detection platforms: NMR, HPLC-UV, LC-MS, GC-MS, and ICP-MS, etc.
Strong professional data statistical classification and bioinformatics analysis.
One-stop customized animal blood metabolomics solution.
Case Study: Plasma Metabolomics Reveals Diet-Induced Metabolic Shifts in Finishing Pigs
BioVenic delivered a one-stop blood plasma metabolomics workflow—from standardized fasting plasma collection and stabilization, through dual-platform LC-MS/MS and GC-MS detection, to multivariate statistics and pathway enrichment analysis. As shown in the figure, the high-protein diet produced a clear metabolic signature: branched-chain amino acids (leucine, isoleucine, valine) and acetylcarnitine rose from low to high levels, reflecting increased protein supply and enhanced fatty acid oxidation, while glucose and urea fell from high to low levels, suggesting improved nitrogen utilization efficiency. By translating nutritional intervention into a multi-analyte, pathway-resolved metabolic readout, BioVenic's end-to-end blood, plasma, and serum metabolomics service supports feed formulation optimization and the discovery of metabolic efficiency biomarkers in livestock production.
Fig. 3 Plasma Metabolite Shifts
Frequently Asked Questions
Q: What are the sample collection and volume requirements for animal blood plasma and serum metabolomics analysis?
A: For optimal metabolomic profiling, we generally recommend collecting at least 100 to 200 microliters of serum or plasma per sample, though specific requirements can vary based on the animal species and the chosen analytical platform. Samples should be collected using standard sterile collection tubes, gently mixed, and centrifuged promptly to separate the supernatant before flash-freezing in liquid nitrogen and storing at -80 degrees Celsius. To avoid freeze-thaw cycles that can degrade unstable metabolites, aliquoting into multiple vials prior to shipping on dry ice is strongly advised. For unusual or precious clinical samples with limited volumes, we suggest reaching out to our technical support team to confirm feasibility and custom handling protocols.
Q: Which animal species are compatible with your metabolomics platform, and can you handle non-model organisms?
A: Our metabolomics platform is highly versatile for a wide range of common livestock, companion animals, and laboratory models including mice, rats, pigs, cattle, sheep, and poultry. We routinely adapt our chromatography-mass spectrometry pipelines to accommodate diverse physiological matrices across these species. If your research involves non-model wild organisms or unique exotic species, matrix effects and endogenous metabolite databases may require specialized optimization. For any rare species or non-standard biological matrices not explicitly listed in our standard service directory, we encourage you to consult our technical support staff to discuss custom method validation.
Q: How should blood samples be prepared and shipped to prevent metabolite degradation during transit?
A: Maintaining sample integrity is critical for metabolomics because post-sampling enzymatic degradation and oxidation can rapidly alter metabolite concentrations. Blood should be allowed to clot for serum preparation or collected in anticoagulant-coated tubes for plasma, followed by immediate centrifugation at 4 degrees Celsius to harvest the clear liquid layer. Samples must be snap-frozen immediately and shipped overnight on a sufficient amount of dry ice to ensure they remain solidly frozen throughout transit. If you encounter logistical challenges regarding international dry-ice shipping or require specialized preservation tubes, please contact our technical support team for guidance.
Q: What analytical platforms do you use for animal serum and plasma metabolomics, and what kind of data output can I expect?
A: We utilize advanced high-resolution liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS) platforms optimized for both untargeted and targeted metabolomic analyses. These robust platforms allow for the comprehensive detection of a broad spectrum of endogenous metabolites such as amino acids, organic acids, lipids, and carbohydrates. The final data package typically includes raw instrument files, cleaned quantitative matrices, compound identification annotations matched against reputable spectral libraries, and comprehensive multivariate statistical reports. If you have specific analytical preferences or require a custom targeted panel, please consult our technical support team to tailor the pipeline to your research goals.
Q: What is the typical turnaround time for an animal metabolomics project, and can it be expedited?
A: A standard animal blood plasma and serum metabolomics project, spanning from sample quality control and metabolite extraction to instrumental acquisition and standard bioinformatics analysis, typically takes around 4 to 6 weeks. The exact duration may fluctuate depending on the current sample queue size, the total batch volume, and whether you require advanced multi-omics correlation or specialized pathway enrichment mapping. We recommend discussing your timeline constraints directly with our technical support team before dispatching your samples.
BioVenic offers personalized metabolomic analysis services for animal blood, plasma, and serum samples to researchers in the fields of life sciences and animal physiology worldwide. You only need to communicate with our technical staff to receive BioVenic's customized animal blood metabolomics program tailored to your specific needs and get accurate and detailed metabolic data and bioinformatics analysis reports. If you encounter any difficulties in the comprehensive analysis and exploration of biomarkers in animal blood, please feel free to contact us.
References
- Kiseleva, Olga, et al. "Defining blood plasma and serum metabolome by GC-MS." Metabolites 12.1 (2021): 15. https://doi.org/10.3390/metabo12010015.
- Image retrieved from Figure 1 "Gene expression pattern analysis", Kiseleva, Olga, et al., 2021, used under CC BY 4.0. The original image was modified by changing title to "Schematic Diagram of Diversity of Metabolic Components in Mammalian Blood".
- Goldansaz, Seyed Ali, et al. "Livestock metabolomics and the livestock metabolome: A systematic review." PloS one 12.5 (2017): e0177675. https://doi.org/10.1371/journal.pone.0177675. Open Access license CC BY 4.0. Without modification.