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Animal lmaging Service
Introduction
Imaging is the "gold standard" for evaluating the effects of drugs on organ structure changes. BioVenic animal imaging research service platform provides imaging services for various experimental animals, including X-ray, computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound. Combined with our capabilities in developing and testing various animal disease models, we can assist you with your animal drug efficacy evaluation and other research.
BioVenic Animal lmaging Services
| Service Category | Modalities & Techniques | Primary Applications | Sample / Subject Requirements |
|---|---|---|---|
| 1. Optical Imaging (In Vivo) | Bioluminescence (Luciferase), Fluorescence (GFP/RFP, Cy5, Cy7, FITC) | Tumor growth & metastasis monitoring, gene expression, cell trafficking, drug distribution. | Live mice, rats; cells, vectors labeled |
| 2. Structural Imaging (Micro-CT) | High-resolution 3D CT, CBCT (Cone Beam CT) | Bone density/microstructure (osteoporosis), dental research, biomaterials (scaffolds/stents), lung/vascular anatomy. | Live rodents or ex vivo samples |
| 3. Functional & Structural MRI | Magnetic Resonance Imaging (T1/T2, fMRI) | Neurological studies (lesions, tumors), cardiovascular morphology, soft tissue imaging (liver, kidney, uterus). | Live animals; requires non-magnetic environment (no metal implants). |
| 4. Nuclear Medicine (PET/CT) | Positron Emission Tomography | Metabolic activity, receptor binding, pharmacokinetics (PK), early-stage lesion detection. | Live animals; requires radiotracers. |
| 5. Advanced Neuroscience | Optogenetics, Chemogenetics, Electrophysiology (Patch Clamp) | Neuronal circuit mapping, behavioral control, ion channel study, synaptic plasticity. | Live rodents; brain slices for patch clamp. |
| 6. Optical Micro-Imaging | Two-Photon Microscopy, Laser Speckle Contrast Imaging (LSCI) | Deep tissue imaging, real-time cerebral blood flow, intravital cellular dynamics. | Live animals with cranial windows or exposed tissue; fluorescent labeling. |
| 7. Neural Tracing | Anterograde & Retrograde Tracing, Vascular Labeling | Mapping neuronal connections (afferent/efferent pathways), neuroanatomy, vascular mapping. | Live animals; stereotaxic injection of viral vectors or dyes |
| 8. Ultrasonography | High-Frequency Ultrasound, Color Doppler, B-mode | Cardiovascular function, hemodynamics, reproductive health, abdominal organ pathology. | Live animals; requires fur removal for acoustic coupling. |
| 9. Bone & Body Composition | Dual-energy X-ray Absorptiometry (DXA/DEXA) | Bone Mineral Density (BMD), body fat percentage, lean mass analysis. | Live animals or carcasses. |
| 10. Physiological Monitoring | Small Animal ECG (Electrocardiogram) | Cardiac rhythm analysis, cardiac safety assessment, heart rate variability. | Live animals (anesthetized or conscious). |
Animal lmaging Service Workflow
BioVenic's streamlined process ensures data integrity and project efficiency:
Core Applications of Animal lmaging Service in In Vivo Research
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Oncology
Metabolism & PK/PD
Advantages of BioVenic Animal lmaging Service
Extensive Model & Cell Libraries
BioVenic maintains a diverse library of established animal models and labeled cell lines, offering customized modeling services to fit your specific research parameters.
Analytical Capabilities
We offer a testing platform and sample analysis to validate findings across different biological levels.
One-Stop Service
Our imaging platform works directly with our animal facility, providing a workflow that reduces complexity and ensures consistent conditions.
What You Receive: The Animal Imaging Final Package
Primary Data Assets: High-quality raw image files (DICOM, TIFF) and processed 2D/3D visualizations.
Quantitative Summary: Tabulated data of all key metrics (e.g., tumor volume, SUV, bone volume fraction, ejection fraction) with statistical analysis.
Comprehensive Study Report: Detailed methodology including animal preparation (anesthesia, labeling, stereotaxic injection), imaging parameters, and expert interpretation of results.
Case Study: Multimodal In Vivo Imaging
BioVenic provides a high-resolution multimodal in vivo imaging service optimized for the longitudinal monitoring of spatiotemporal dynamics in complex breast cancer xenograft models. We offer an integrated pipeline utilizing bioluminescence imaging (BLI) for highly sensitive, whole-body tracking of luciferase-tagged cells, enabling the detection of early-stage micrometastases. Optical data, CT, and MRI provide volumetric quantification and localization of metastatic lesions in critical organs such as the lungs and brain. By delivering high-fidelity data, we provide a robust framework for screening novel anti-metastatic therapeutics and validating diagnostic biomarkers, offering the necessary imaging evidence to accelerate the clinical management of advanced malignancies.
Fig. 1 Representative BLI and CT images of primary tumors before resection1
FAQs
Is your facility suitable for non-GLP pilot studies?
BioVenic animal imaging services are optimized for high-quality non-GLP preclinical research, providing the rigorous data needed for internal decision-making and regulatory filings.
Which animal species are supported by your imaging services?
Our imaging services are primarily optimized for small animal models, specifically rats and mice. However, we understand that certain research projects require specialized models. Our team can also assess feasibility for other species to provide necessary imaging support with high data quality.
What are the timelines and pricing for your imaging services?
As an integral component of in vivo studies, our imaging services are seamlessly incorporated into the overall research timeline. Because each project varies in complexity-including the number of time points, the imaging modalities used, and the specific disease models-tailored timelines and pricing are provided after a comprehensive project evaluation by our scientific experts.
Contact Us
BioVenic has multiple imaging capacities and a team of experienced veterinary imaging specialists. In animal efficacy evaluation, data is always the most powerful language. Don't let the "blurriness" to the naked eye become a weakness in front of reviewers. Imaging data is not just "pictures," but solid evidence that can be directly used in reports. BioVenic's professional team is ready to assist you, ensuring your experiment progresses smoothly without delays due to scheduling conflicts. From proposal to report, our transparent service process lets you focus on research and development. Contact our team for a consultation and a custom quote for your imaging needs.
Reference
- Fricke, Inga B et al. "Spatiotemporal assessment of spontaneous metastasis formation using multimodal in vivo imaging in HER2+ and triple negative metastatic breast cancer xenograft models in mice." PloS one vol. 13,5 e0196892. 3 May. 2018. https://doi.org/10.1371/journal.pone.0196892. Distributed under Open Access license CC BY 4.0. Figure 1(A) was extracted.