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Preclinical Large Animal Solution
Introduction
At the critical junction between lead optimization and clinical entry, BioVenic's Preclinical Large Animal Solution provide high-fidelity, non-GLP in vivo research services. Integrating advanced disease modeling, bioanalysis, and imaging in large animals, BioVenic provides data that simplifies preclinical work. We support your decisions with strong evidence, reducing risks before regulatory trials.
Our Services
Precision Large Animal Model Construction
BioVenic offers validated and customizable large animal disease models designed to mimic complex human pathologies. Our expertise covers model adaptation and bespoke development:
| Application Area | Common Models | Induction Methods |
|---|---|---|
| Orthopedics | Rabbit, Canine, Porcine | Surgical osteotomy, bone defect creation, or internal fixation |
| Cardiovascular | Porcine, Canine | Vessel ligation (MI), balloon injury, or aortic banding (TAC) |
| Dermatology | Porcine, Rabbit | Full-thickness wounding, thermal injury, or chemical induction |
| Metabolic | NHP, Porcine, Canine | High-fat diet induction or chemical-induced pancreatic impairment |
| Oncology | Rabbit, Canine | Orthotopic or subcutaneous tumor cell/fragment implantation |
Specialized Biospecimen Collection
Accuracy starts at the source. BioVenic's veterinary technicians perform professional sampling, processing, and stabilization of diverse biological matrices:
Tissues: Biopsies of bone, skin, muscle, and major organs.
Fluids: Blood collection, cerebrospinal fluid (CSF), bile, urine, and synovial fluid.
Cells: Cell isolation from bone marrow or lymphoid tissues.
All samples are preserved and transported with validated cold-chain protocols for integrity.
Comprehensive Bioanalytical Detection
Utilizing a multi-omic approach, BioVenic evaluates biochemical signatures to assess model validity and efficacy:
Protein Analysis: Quantification of cytokines and biomarkers using ELISA and Western Blot.
Gene Expression: Target engagement and pathway analysis using qPCR.
Safety Biomarkers: Blood chemistry and hematology panels.
Specialized Histopathology
BioVenic's pathology suite provides deep structural insights into tissue transformations:
- Standard H&E staining and specialized histological staining (e.g., Masson's Trichrome).
- Immunohistochemistry (IHC): Protein localization and expression density analysis.
- Expert pathological scoring and digital slide scanning for remote review.
Advanced In Vivo Imaging
BioVenic uses non-invasive imaging to track disease progression and drug distribution:
Structural & Functional Imaging: High-field MRI and CT for measuring tumor size and bone healing.
Metabolic Mapping: PET/CT for real-time metabolic activity and tracer distribution.
Interventional Support: Ultrasound and X-ray for guided micro-invasive procedures.
Optical Imaging: Fluorescence tomography for cell tracking and monitoring.
Large Animal Pharmacodynamics (PD) Studies
BioVenic's large animal pharmacodynamics (PD) studies aim to establish a Dose-Response relationship in a relevant system.
Key Services: Target engagement studies, biomarker kinetics, and functional recovery assessment (e.g., motor skills, cardiac output).
Large Animal Pharmacokinetics (PK) Studies
BioVenic's large animal pharmacokinetics (PK) studies help determine how the body processes your compound across various delivery routes.
Key Services: Single/multiple dose PK, bioavailability studies (PO/IV/SC/IT), food effect evaluations, and tissue distribution profiling.
BioVenic Preclinical Large Animal Study Workflow
Advantages of BioVenic Preclinical Large Animal Solution
Superior Translational Relevance
Large animals like dogs and pigs have similarities to humans that rodents do not. This is crucial for cardiovascular, neurological, orthopedic, and metabolic research.
Bespoke Model & Cell Library
We have a library of large animal primary cells and offer model engineering for unique research needs.
Integrated Analytical Platform
Our seamless transition from in-life phases to high-sensitivity bioanalysis ensures data continuity and reduces lead times.
One-Stop Efficiency
From initial consultation to the final study report, we manage the entire workflow, allowing you to focus on the science while we handle the operational complexity.
What You Get: Preclinical Large Animal Solution Deliverables
To ensure your preclinical program is decision-ready and clinically relevant, BioVenic provides comprehensive data packages and high-quality biological materials across every stage of model construction and evaluation.
Stage 1: Precision Model Construction & Validation
Outputs:
- Validated Disease Model: A customized large animal model (NHP, Porcine, Canine, or Rabbit) mimicking specific human pathologies.
- Surgical/Induction Summary: Detailed report on the induction method used (e.g., osteotomy, vessel ligation, or chemical impairment).
- Baseline Characterization: Initial physiological data confirming successful model establishment.
Stage 2: Specialized Biospecimen & Bioanalytical Package
Deliverables:
- Stabilized Biological Matrices: Professional collection of diverse samples (CSF, synovial fluid, bile, or isolated bone marrow cells) preserved via validated cold-chain protocols.
- Molecular Signature Report: Multi-omic data including protein quantification (ELISA/Western Blot) and gene expression (qPCR) for target engagement.
- Safety & Hematology Panel: Comprehensive blood chemistry and hematology profiles to assess systemic health.
Stage 3: Advanced Imaging & Histopathology Insights
Outputs:
- Multi-Modal Imaging Data: High-resolution structural and functional scans (MRI, CT, or PET/CT) tracking disease progression or bone healing.
- Structural Transformation Analysis: Expert pathological scoring and digital slides, including standard H&E and specialized stains (e.g., Masson's Trichrome).
- IHC Localization Mapping: Immunohistochemistry reports detailing protein localization and expression density within tissues.
Stage 4: Comprehensive PK/PD Evaluation Report
Deliverables:
- Pharmacodynamic (PD) Profile: Establishment of dose-response relationships, biomarker kinetics, and functional recovery assessments (e.g., cardiac output).
- Pharmacokinetic (PK) Dataset: Full profiling of compound processing across various routes (PO/IV/SC/IT), including bioavailability and tissue distribution.
- Food Effect & Dosing Analysis: Evaluation of external factors on drug absorption and single/multiple-dose PK parameters.
Case Study: PK and Safety Evaluation of Novel Triterpenoid Saponins in Beagle Dogs
BioVenic provides a comprehensive large animal solution for characterizing the pharmacokinetic (PK) profiles and systemic safety of novel anti-inflammatory compounds in Beagle dogs. This service is designed to determine key parameters such as bioavailability, dose proportionality, and toxicity under both single and repeated dosing regimens. We utilize HPLC-MS/MS methods for the high-sensitivity quantification of plasma drug concentrations, integrated with a rigorous safety assessment suite including hematology, serum biochemistry, and multi-organ histopathology. This integrated workflow is specifically optimized to establish fundamental safety margins and dosing parameters required for veterinary clinical development. By delivering high-fidelity kinetic data and verifying the absence of organ-specific toxicity, we provide the robust evidence-based framework necessary to validate therapeutic candidates for canine inflammatory conditions.
Fig. 1 Concentration-time curve of AB4 in dogs after single dose1
FAQs
What administration routes do you support for large animals?
We support many routes like oral (tablet/capsule), intravenous (bolus or infusion), subcutaneous, intramuscular, and special routes like intrathecal or intra-articular injections.
Can you customize a model if it's not in your standard catalog?
Our senior scientists specialize in surgical and chemical model creation. We work with you to develop and validate custom models for your drug's specific action.
How do you handle sample stability during long-term studies?
We have on-site labs for sample processing. Samples are processed right away (e.g., centrifugation, flash-freezing) and stored in monitored ultra-low temperature areas.
Contact Us
Elevate your preclinical program with data you can trust. BioVenic's Preclinical Large Animal Solutions combine veterinary surgery, imaging, and bioanalysis to validate therapeutic ideas. Whether optimizing leads or gearing for clinical trials, our team is ready to speed up your process with accuracy and reliability. Connect with our senior scientists for a project evaluation and quote.
Reference
- Ji, Jinzhao, et al. "Pharmacokinetics and safety evaluation of anemoside B4 in healthy Beagle dogs." Frontiers in Veterinary Science 12 (2025): 1645372. https://doi.org/10.3389/fvets.2025.1645372. Distributed under Open Access license CC BY 4.0. Without modification.