Faced with the challenge of animal bacterial infection and their potential zoonotic impact, BioVenic offers a full suite of veterinary bacterial vaccine development services. From antigen discovery to safety assessment, we are equipped with advanced tools and extensive expertise to design and test highly effective vaccines that safeguard animal health and public welfare by preventing veterinary bacterial diseases.
Our Services
Bacteria have a large number of coding genes and a very complex antigenic structure consisting of external and internal antigens, including toxins. It is extremely important to predict which antigens are likely to produce an appropriate immune response in order to select the right antigens for veterinary vaccine preparation. BioVenic offers services to identify potential vaccine candidates, such as the use of inverse vaccinology to find suitable protein targets, in addition to the traditional identification and screening of pathogenic bacteria, so that your vaccine development has a reassuring immunogenicity on animals.
Fig.1 Bacterial structures recognizable by the host immune system.1
Bacterial Culture
The culture process of bacteria for veterinary vaccines is very critical for the quality and yield of vaccines. After completing the strain screening, BioVenic is capable of establishing bacterial seed lots and using the target strains to culture them on suitable media to improve the production efficiency of the bacteria and to ensure the integrity of the antigenicity of the organisms.
Bacterial Attenuation, Inactivation, Deactivation, and Validation
For some types of veterinary bacterial vaccines, it is necessary to attenuate or inactivate the strains or detoxify the toxins produced by the bacteria. BioVenic provides the above services to assist in the production of antigens, as well as validation services to ensure that the attenuation, inactivation, deactivation are completed, and that residual vaccine inactivation agent has been detected to prevent any immunotoxicity and negative immune response of vaccines on animals.
Veterinary Bacterial Vaccine Development Platforms
There are many types of vaccines that suit for animal bacterial infections. Besides the most common live attenuated vaccines, there are also whole-cell vaccines, toxoid vaccines and vaccines that rely on new technologies. Company has established vaccine development platforms for different type of bacterial vaccine development.
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Platforms
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Description
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Advantages
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Limitations
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Live Attenuated Bacterial Vaccine
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Pathogens with reduced virulence.
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Possible local side effects.
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High requirements for storage and transportation.
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Toxoid Vaccine
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Toxins with loss of toxicity.
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Safe
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Strong and specific immune response
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Easy to manufacture
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Possible immune response to vector
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Whole Cell Bacterin Vaccine
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Killed cells of one or
more bacteria.
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Presentation of many antigens.
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Zero virulence potential.
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Adjuvant-like character.
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High doses required.
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Short-term immunity.
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Inability to offer cross-serotype protection.
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Carbohydrate-based Subunit Bacterial Vaccine
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Carbohydrates from pathogens.
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Poor immune response.
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Multiple doses required.
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Conjugate Bacterial Vaccine
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Antigen chemically linked to a stronger antigen.
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High costs due to complex formulations.
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Applications of Veterinary Bacterial Vaccines
With the introduction of antibiotics, the emphasis on their usage for preventing bacterial infections has impacted the pace of veterinary bacterial vaccine research. This has resulted in a slower development compared to viral vaccines. Addressing antibiotic resistance, a worldwide concern for animal health, novel veterinary bacterial vaccines hold the potential to not only decrease farmed animal bacterial infectious diseases but also curtail antibiotic consumption and antibiotic resistance.
Our Advantages
Comprehensive Strain Selection
BioVenic carefully identifies and selects the best bacterial strains for animal vaccine development.
Customized Antigen Discovery
Leveraging our knowledge of bacterial pathogens, we provide identification and characterization of key immunogens, laying the foundation for precise vaccine design.
Robust Immunogenicity Assessment
Our advanced in vitro and in vivo assays evaluate the immunogenic potential of antigens, ensuring that your bacterial vaccine will trigger a strong protective immune response in animals.
Rigorous Safety Assessment
BioVenic prioritizes animal health through preclinical safety assessments to ensure that our vaccine development services develop safe and effective veterinary vaccines for livestock, poultry, companion animals, aquaculture species and more.
Advanced Vaccine Formulation
Our experts are able to design vaccine formulations that optimize antigen presentation, immune recognition and long-term protection.
BioVenic has deep expertise in bacterial veterinary vaccine development, with comprehensive services including strain selection, antigen discovery, immunogenicity assessment and safety assessment. We are committed to creating effective solutions to safeguard animal health. Contact us! Explore how our veterinary bacterial vaccine development expertise addresses your specific needs. Let's collaborate to enhance animal well-being and bring effective vaccine solutions to life.
References
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Giesker, K., and Hensel, M. "Bacterial Vaccines." Reference module in biomedical sciences (2014).
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Pace, John L., et al. "Inactivated whole-cell bacterial vaccines: current status and novel strategies." Vaccine 16.16 (1998): 1563-1574..
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Micoli, Francesca, et al. "Strengths and weaknesses of pneumococcal conjugate vaccines." Glycoconjugate Journal 40.2 (2023): 135-148.
