This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Preclinical Companion Animal Solution
Introduction
BioVenic's comprehensive Preclinical Companion Animal Solution offers end-to-end support for feline and canine models. From building complex models to multi-parameter biochemical analysis and cutting-edge nutritional science, we make the non-GLP preclinical workflow easy. Although we focus on dogs and cats, we offer the right reagents and high-quality service for your diverse species research, like horses.
Our Services
Companion Animal Model Construction
Leveraging our deep expertise in feline and canine physiology, BioVenic offers both established model adaptation and custom de novo development. Our capabilities span natural genetic predispositions, surgical inductions, and pharmacologically induced pathologies.
| Species | Disease Category | Specific Model | Induction Method / Type |
|---|---|---|---|
| Feline (Cat) | Cardiovascular | Hypertrophic Cardiomyopathy (HCM) | MYBPC3 mutation (Spontaneous/Homologous) |
| Arteriovenous Fistula Thrombosis | Surgical induction | ||
| Metabolic | Type 2 Diabetes Mellitus (T2DM) | High-fat diet (HFD) + STZ-induced | |
| T2DM | Total splenectomy + Partial pancreatectomy + Glucocorticoids | ||
| Obesity | Diet-induced | ||
| Renal & Urology | Chronic Kidney Disease (CKD) | Spontaneous or induced | |
| Polycystic Kidney Disease (PKD) | PKD1 mutation (Homologous) | ||
| Acute Kidney Injury (AKI) | Ischemia-Reperfusion Injury (IRI) | ||
| Neurological | Spontaneous Alzheimer's Disease (AD) | Age-related/Congenital | |
| Glaucoma | Congenital or Intracameral Methylcellulose injection | ||
| Infectious Disease | Feline Immunodeficiency Virus (FIV) | Viral challenge | |
| Feline Infectious Peritonitis (FIP) | Viral challenge | ||
| Orthopedic & Pain | Chronic/Inflammatory Pain | Subcutaneous Kaolin injection (paw pad) | |
| Osteoarthritis (OA) | Sodium Iodoacetate (MIA) or Surgery (DMM+ACLT) | ||
| Canine (Dog) | Cardiovascular | Dilated Cardiomyopathy (DCM) | Spontaneous (Doberman) or Tachycardia-pacing induced |
| Myocardial Infarction (MI) / Heart Failure | IRI, Coronary Ligation, or Pacemaker-induced | ||
| Hypertension | Renal/Abdominal Aortic Constriction or Diet-induced | ||
| Atrial Fibrillation (AF) | Pacemaker-induced or Acetylcholine-induced | ||
| Neurological | Stroke (Ischemic/Hemorrhagic) | Permanent Ischemia or Collagenase-induced | |
| Parkinson's Disease (PD) | MPTP-induced | ||
| Spinal Cord Injury (SCI) / Autism | Complete transection / Gene Knockout (KO) | ||
| Orthopedic | Non-union / Alveolar Bone Defect | Surgical resection | |
| Hip Replacement / Osteoarthritis | Prosthetic implantation / MIA-induced | ||
| Sarcopenia | High-fat diet induced | ||
| Gastrointestinal | Inflammatory Bowel Disease (IBD) | DSS-induced or Acetic Acid-induced | |
| Dermatology | Atopic Dermatitis (AD) | DNCB-induced | |
| Other Models | Benign Prostatic Hyperplasia (BPH) | Spontaneous / Hormone-induced | |
| Genetic Models (e.g., APOE) | Gene Editing |
Specialized Companion Animal Biosampling
Precision in large animal research begins with expert sampling. BioVenic's technicians are proficient in the collection and processing of diverse matrices, including tissues, cells, and biofluids (blood, urine, CSF, etc.). Samples are handled, stabilized, and preserved according to strict protocols to ensure downstream analytical integrity.
Companion Animal Biochemical Analysis
BioVenic provides a robust platform for the characterization of companion animal biosamples. Our services integrate:
Immunoassays: Comprehensive ELISA Product Line for biomarker quantification.
Molecular Diagnostics: High-sensitivity qPCR products and services for gene expression profiling.
Standard Profiles: Clinical biochemistry, hematology, and urinalysis.
Protein Analysis: Western Blotting (WB) and customized protein characterization.
Veterinary Pathology Services
BioVenic's pathology suite offers detailed insights into organ and tissue alterations. We provide expert histological sectioning, specialized staining, and digital slide reading, followed by comprehensive pathological reporting and interpretation by experienced veterinary pathologists.
In Vivo Pharmacokinetics & Efficacy for Companion Animals
We perform robust, non-GLP companion animal preclinical studies to assess:
Drug Metabolism & PK: The rate of absorption, distribution, and clearance in the target species.
In Vivo Efficacy: Quantitative measurement of a biological effect in a particular disease model.
Early Toxicology: Safety and tolerability screening before advancing to large scale studies.
Food Palatability & Nutritional Research for Companion Animals
Optimize your product's market appeal through our Companion Animal Food Palatability Studies. We conduct intake preference tests and nutritional metabolism research to validate dietary formulations and functional supplements.
BioVenic Preclinical Companion Animal Service Workflow
Figure. 1 Workflow (BioVenic AI)
Advantages of BioVenic Preclinical Companion Animal Solution
Diverse Model & Cell Library
Access an extensive repository of canine and feline disease models (genetic, diet-induced, and surgical). Our specialized companion animal cell bank provides a powerful foundation for in vitro to in vivo correlation.
Customized Development
We don't just offer "off-the-shelf" solutions; our scientists collaborate with you to design bespoke models tailored to your specific molecule's mechanism of action.
Standardized Detection Platforms
Benefit from a unified analytical ecosystem capable of processing multi-matrix samples with high reproducibility and sensitivity.
Integrated One-Stop Solution
Eliminate logistical hurdles. Our ability to link model construction directly with downstream PK/PD sampling and biochemical analysis ensures a seamless research transition.
What You Get: Preclinical Companion Animal Solution Deliverables
To ensure your veterinary drug or nutritional project is milestone-driven and data-ready, our programs provide clear, high-quality deliverables across the entire preclinical spectrum-from model construction to final efficacy reporting.
Stage 1: Companion Animal Model Construction & Validation
Outputs:
- Customized Study Design: A detailed protocol selecting either established feline/canine model adaptation or de novo development (Genetic, Surgical, or Pharmacological induction).
- Baseline Characterization Data: Verification of the disease state (e.g., HCM mutations in cats, pacing-induced DCM in dogs, or dietary-induced obesity metabolic profiles) via imaging or biomarkers.
- Model Stability Report: Longitudinal data confirming the pathological phenotype's consistency for the duration of your study.
Stage 2: Precision Biosampling & Biochemical Analysis
Deliverables:
- Stabilized Matrix Repository: Professionally processed tissues, cells, and biofluids (Blood, Urine, CSF) handled under strict preservation protocols.
- Biochemical Profiling Package: Comprehensive data sets including:
- Immunoassays: Biomarker quantification via our proprietary ELISA product line.
- Molecular Diagnostics: High-sensitivity qPCR gene expression profiling.
- Standard Clinical Panels: Hematology, clinical biochemistry, and urinalysis results.
- Protein Characterization: Western Blotting (WB) results and specialized protein analysis.
Stage 3: Veterinary Pathology & Interpretation
Outputs:
- High-Resolution Imaging: Digital slide readings and histological sectioning with specialized staining.
- Pathological Assessment Report: Detailed insights into organ and tissue alterations.
- Expert Interpretation: Formal summary and conclusion provided by experienced veterinary pathologists to guide your mechanism-of-action (MoA) understanding.
Stage 4: In Vivo PK/PD & Efficacy Package
Deliverables:
- Pharmacokinetic (PK) Profile: Detailed absorption, distribution, and clearance rates in the target species (Feline or Canine).
- Efficacy Validation Report: Quantitative measurement of biological effects and therapeutic outcomes within the specific disease model.
- Safety & Tolerability Summary: Early-stage toxicology screening data, including "No Observed Adverse Effect Level" (NOAEL) indicators, to de-risk large-scale studies.
Stage 5: Palatability & Nutritional Research
Outputs:
- Intake Preference Data: Comparative results from food palatability studies to optimize market appeal.
- Nutritional Metabolism Report: Data validating dietary formulations and the metabolic impact of functional supplements.
Case Study: Preclinical Therapeutic Efficacy in Canine Osteoarthritis Models
BioVenic provides a companion animal solution for evaluating the chondroprotective and anti-inflammatory effects of novel pharmacological agents. Utilizing a specialized Beagle model of osteoarthritis (OA), we offer a robust environment for assessing joint degeneration and pain management efficacy. Our analytical suite features a comprehensive histological-biochemical joint assessment, employing a scoring system to precisely quantify cartilage erosion and proteoglycan loss. This is complemented by ELISA analysis of synovial fluid to measure key pro-inflammatory markers such as TNF-alpha and IL-1beta. To track structural remodeling, our platform integrates micro-CT imaging to assess subchondral bone changes and osteophyte volume. This integrated workflow is specifically designed to validate the ability of therapeutic candidates to preserve cartilage integrity and suppress inflammatory cascades, providing a rigorous scientific basis for their application in veterinary orthopedics.
Fig. 2 Histological examination in a canine model of OA1
FAQs
Do you conduct studies on client provided samples?
We not only build the models but also receive the biological samples for stand-alone biochemical, molecular or pathology analysis.
Do you provide support for testing of nutritional supplements?
We have the in-house metabolic capability to follow changes in weight, metabolic markers and palatability on new pet food and supplement ideas.
Is your laboratory AAALAC and IACUC compliant?
All studies performed at our facility are in accordance with IACUC guidelines and comply with the 3R principles.
Contact Us
From complex surgical model induction to high-throughput biochemical screening, BioVenic's Preclinical Companion Animal Solution is designed to mitigate R&D risk and provide a clear path toward your research milestones. We combine veterinary expertise with industrial-grade precision to deliver data you can trust. Ready to elevate your preclinical program? Contact us today for a technical consultation and a customized quote.
Reference
- Kim, Hye-Min, et al. "Effects of SKCPT on Osteoarthritis in Beagle Meniscectomy and Cranial Cruciate Ligament Transection Models." International Journal of Molecular Sciences 24.19 (2023): 14972. https://doi.org/10.3390/ijms241914972. Distributed under Open Access license CC BY 4.0. Without modification.