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Rabbit Anti-Mouse Histone Acetyltransferase 1 (HAT1) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse histone acetyltransferase 1. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse histone acetyltransferase 1.
Specifications
Target Information
Mouse histone acetyltransferase 1 (HAT1) is a 49 kDa type-B enzyme whose N-terminal HAT domain transfers acetyl-CoA to histone H4 lysines 5 and 12, while a C-terminal tail binds nascent histone H3-H4 dimers in the cytoplasm. A solvent-exposed 16-residue "QRR" loop (aa 130-145) bridging β6 and α4 folds into a β-hairpin unique among HAT family members, presenting a conformational epitope preserved after fixation. Affinity-purified antibodies targeting this loop trace native HAT1 in nuclear speckles, cytosolic pre-histone complexes, and embryonic stem cells, delivering crisp punctate staining and single-band clarity on immunoblots with no cross-reaction to p300 or GCN5.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.