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Rabbit Anti-Mouse Liver X Receptor Alpha (LXRa) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse liver X receptor alpha. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse liver X receptor alpha.
Specifications
Target Information
Mouse liver X receptor alpha (LXRα, NR1H3) is a 54-kDa nuclear receptor predominantly expressed in mouse liver, adipose tissue, and macrophages. Activated by endogenous oxysterols, it forms heterodimers with retinoid X receptor (RXR) to regulate transcription of genes involved in cholesterol efflux (ABCA1, ABCG1), lipid metabolism, and inflammatory responses. Critical for murine cholesterol homeostasis, reverse cholesterol transport, and macrophage foam cell formation, it modulates metabolic and inflammatory pathways linked to atherosclerosis and fatty liver disease. Dysregulated activity associates with dyslipidemia and metabolic syndrome. As a key mediator of lipid metabolism and inflammation, mouse LXRα is a critical target for studying metabolic disorders, atherosclerotic pathobiology, and lipid-modulating therapeutics.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.