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Rabbit Anti-Mouse Regulator of G Protein Signaling 5 (RGS5) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse regulator of G protein signaling 5. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse regulator of G protein signaling 5.
Specifications
Target Information
Mouse regulator of G-protein signaling 5 (RGS5) is a 19 kDa cysteine-rich GAP whose N-terminal amphipathic helix docks onto activated Gαq, while a C-terminal tail binds PDZ scaffolds at pericyte and vascular smooth-muscle membranes. A solvent-exposed "GAP" loop (aa 120-135) houses the catalytic asparagine unique among RGS subtypes, presenting a conformational epitope that survives aldehyde fixation. Polyclonal antibodies targeting this loop trace native RGS5 in retinal vessels, tumor stroma, and renal mesangium, yielding crisp mural-cell rims and single-band clarity on immunoblots with no cross-reaction to RGS2 or RGS4.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.