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Rabbit Anti-Rat Cubilin (CUBN) Polyclonal Antibody

Cat. No.VD3N255

Product TypeVeterinary Antibodies

Size

Product Overview

BioVenic rabbit polyclonal antibody is specific for rat cubilin. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of rat cubilin.

Specifications

Application WB; IHC; ICC; IP
Clonality Polyclonal
Classification Primary Antibody
Clone C1N6
Host Rabbit
Target Species Rat
Species Reactivity Rat
Specificity Rat Cubilin
Isotype IgG
Immunogen Recombinant protein of rat cubilin
Purification Purified by Protein A
Concentration 0.63 mg/mL
Conjugation Unconjugated
Preservative and Stabilizer 0.05% Proclin 300
Buffer 0.01M Phosphate Buffered Saline, pH 7.4, with 50% glycerol
Physical State Liquid

Target Information

Rat Cubilin is a multifunctional receptor involved in the endocytic uptake of various molecules, including vitamins, lipoproteins, and other essential nutrients. It is highly expressed in the renal proximal tubules and the yolk sac, where it plays a crucial role in the reabsorption of filtered proteins and the transport of nutrients. Cubilin is also involved in the regulation of cholesterol metabolism. Targeting Cubilin with specific antibodies allows for detailed investigation of its role in renal physiology, nutrient absorption, and lipid metabolism.

Target Rat Cubilin
Target Synonym IFCR; MGA1; gp280; Intrinsic Factor Cobalamin Receptor; 460 kDa receptor
Gene ID 80848
UniProt ID O70244

Shipping and Storage

This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.

Documents

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

References

  1. Birn, Henrik, et al. "Cubilin is an albumin binding protein important for renal tubular albumin reabsorption." The Journal of clinical investigation 105.10 (2000): 1353-1361. https://doi.org/10.1172/JCI8862
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