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Rabbit Anti-Mouse X-Ray Repair Cross Complementing 5 (XRCC5) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse X-ray repair cross complementing 5. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse X-ray repair cross complementing 5.
Specifications
Target Information
Mouse X-ray repair cross-complementing 5 (XRCC5) is a 70-kDa DNA repair protein ubiquitously expressed in murine tissues, with enriched levels in proliferative cells (bone marrow, intestinal epithelium) and germline cells. It forms a heterodimer with XRCC6 (Ku70/Ku80 complex), initiating non-homologous end joining (NHEJ) to repair double-strand DNA breaks (DSBs) induced by radiation, oxidative stress, or replication errors. Critical for maintaining murine genomic stability, cell survival, and immune receptor V(D)J recombination, it modulates DNA damage response pathways. Dysregulated expression associates with carcinogenesis, radiosensitivity, and immunodeficiency in mouse models. As a key mediator of DSB repair, mouse XRCC5 is a critical target for studying DNA repair mechanisms, cancer radiotherapy resistance, and genome-editing related therapeutics.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.