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Rabbit Anti-Rat T-Cell Immunoreceptor with Ig and ITIM Domains Protein (TIGIT) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat T-cell immunoreceptor with Ig and ITIM domains protein. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of rat T-cell immunoreceptor with Ig and ITIM domains protein.
Specifications
Target Information
Rat T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a 26 kDa type-I transmembrane glycoprotein whose N-terminal IgV domain binds CD155 and CD112, while a C-tail ITIM recruits SHIP-1 to dampen NK and T-cell activation. A solvent-exposed 14-aa "SKP" loop (aa 52-65) between β-strands C and C' folds into a β-hairpin unique among rat Ig superfamily members, presenting a fixation-stable epitope absent from CD96 or DNAM-1. Affinity-purified antibodies targeting this loop trace native TIGIT in splenic NK cells, CD8+ T-cell follicles, and lamina propria lymphocytes, delivering crisp surface rings and single-band clarity on immunoblots with no cross-reaction to other coinhibitory receptors.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.