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Rabbit Anti-Rat Insulin Receptor Substrate 2 (IRS2) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat insulin receptor substrate 2. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of rat insulin receptor substrate 2.
Specifications
Target Information
Rat Insulin Receptor Substrate 2 (IRS2) is an essential cytoplasmic adaptor protein that links activated insulin and IGF-1 receptors to downstream signaling cascades. Phosphorylated on multiple tyrosine residues, IRS2 recruits and activates PI3K and other effectors, thereby regulating glucose uptake, glycogen synthesis, β-cell survival, and lipid metabolism. It is highly expressed in liver, skeletal muscle, pancreatic islets, and brain, serving as a critical node in metabolic control. Loss or mutation of IRS2 disrupts insulin sensitivity and glucose homeostasis, making it a key target for studies of diabetes, metabolic syndrome, and growth regulation.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.