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Rabbit Anti-Mouse Pregnane X Receptor (PXR) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse pregnane X receptor. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse pregnane X receptor.
Specifications
Target Information
Mouse Pregnane X Receptor (PXR) is a nuclear receptor that regulates the expression of genes involved in drug metabolism and detoxification. It is activated by a wide range of xenobiotics and endogenous compounds, leading to the induction of enzymes such as cytochrome P450. PXR is highly expressed in tissues like the liver and intestines, where it plays a crucial role in maintaining metabolic homeostasis. Targeting PXR with specific antibodies allows for detailed investigation of its role in pharmacology and toxicology, making it a valuable tool for studying drug interactions and metabolic pathways.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Squires, E. James, Tatsuya Sueyoshi, and Masahiko Negishi. "Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver." Journal of Biological Chemistry 279.47 (2004): 49307-49314. https://doi.org/10.1074/jbc.M407281200