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Rabbit Anti-Mouse Glutamate Receptor (GRIA3) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse glutamate receptor, ionotropic, AMPA 3. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse glutamate receptor, ionotropic, AMPA 3.
Specifications
Target Information
Mouse GRIA3 encodes the 894-residue AMPA-preferring glutamate receptor subunit GluA3. The ectodomain assembles into clamshell-like binding pockets that gate sodium flux upon glutamate occupancy. A unique 12-amino-acid insertion within the N-terminal tail, absent in rat or human orthologs, creates an exposed surface loop that remains accessible after tetramer assembly. Antibodies binding this segment lock the receptor in a closed conformation, silencing excitatory currents in cortical and hippocampal neurons without cross-reacting with GluA1, GluA2 or GluA4 subunits.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.