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Rabbit Anti-Rat Cytochrome P450 1A1 (CYP1A1) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat cytochrome P450 1A1. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of rat cytochrome P450 1A1.
Specifications
Target Information
Rat cytochrome P450 1A1 (CYP1A1) is a 58-kDa microsomal monooxygenase predominantly expressed in rat liver, lung, and intestinal mucosa, with inducible expression in extrahepatic tissues. It catalyzes the oxidation of polycyclic aromatic hydrocarbons (PAHs), xenobiotics, and endogenous compounds, mediating their metabolism and detoxification or bioactivation. Critical for rat xenobiotic clearance and chemical defense, it modulates pathways involved in oxidative stress and cellular homeostasis. Dysregulated induction associates with chemical-induced carcinogenesis, hepatotoxicity, and pulmonary damage in rat models. As a key mediator of xenobiotic metabolism, rat CYP1A1 is a critical target for studying toxicological pathobiology and developing xenobiotic-induced disease therapeutics.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.