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Rabbit Anti-Mouse Angiotensin I Converting Enzyme (ACE) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse angiotensin I converting enzyme. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse angiotensin I converting enzyme.
Specifications
Target Information
Mouse angiotensin I converting enzyme (ACE, CD143) is a 130 kDa type-I dipeptidyl carboxypeptidase whose two homologous catalytic domains cleave angiotensin I and bradykinin, regulating blood pressure and inflammation. A solvent-exposed 14-aa "KVE" loop (aa 620-633) within the C-domain active site folds into a β-hairpin unique among mouse metallopeptidases, presenting a conformational epitope preserved after fixation. Affinity-purified antibodies targeting this loop trace native ACE in pulmonary capillary endothelium, renal proximal tubules, and splenic follicles, delivering crisp apical membranes and single-band clarity on immunoblots with no cross-reaction to ACE2 or other peptidases.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.