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Rabbit Anti-Mouse Toll Like Receptor Adaptor Molecule 1 (TICAM1) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse toll like receptor adaptor molecule 1. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse toll like receptor adaptor molecule 1.
Specifications
Target Information
Mouse Toll-Like Receptor Adaptor Molecule 1 (TICAM1, TRIF) is a cytoplasmic adaptor essential for TLR3 and TLR4 signal transduction. Upon ligand binding, TICAM1 recruits kinases and ubiquitin ligases, activating IRF3 and NF-κB to drive type-I interferon and pro-inflammatory cytokine production. Expressed in macrophages, dendritic cells, and fibroblasts, it bridges innate pathogen sensing to antiviral immunity. Loss of TICAM1 impairs host defense and alters inflammatory balance. As a critical node in TLR signaling, TICAM1 is an important target for studies of infection, inflammation, and vaccine adjuvanticity.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.