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Rabbit Anti-Rat Meprin A Beta (MEP1b) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat meprin A beta. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of rat meprin A beta.
Specifications
Target Information
Rat meprin A beta is a 85 kDa zinc metallo-endopeptidase whose N-terminal astacin domain cleaves acidic and hydrophobic residues, while a C-terminal MAM module anchors the membrane dimer. A solvent-exposed 14-aa "KVE" loop (aa 285-298) between the active-site helix and methionine-rich plug folds into a β-hairpin unique among rat astacin proteases, presenting a conformational epitope preserved after activation and fixation. Affinity-purified antibodies targeting this loop trace native meprin A beta in renal brush-border membranes, intestinal epithelium, and neutrophil granules, delivering crisp apical rims and single-band clarity on immunoblots with no cross-reaction to meprin A alpha or meprin B.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.