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Rabbit Anti-Mouse Pronociceptin (PNOC) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse pronociceptin. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse pronociceptin.
Specifications
Target Information
Mouse pronociceptin (PNOC) is a 19 kDa precursor whose C-terminal heptapeptide flanks nociceptin/orphanin-FQ, a ligand for the opioid-receptor-like-1 (NOP) receptor that dampens pain and stress signals. A solvent-exposed 14-aa "KVE" loop (aa 95-108) between the Arg-Arg cleavage site and the mature peptide folds into a β-hairpin unique among mouse opioid precursors, presenting a conformational epitope preserved after pro-hormone convertase processing and fixation. Affinity-purified antibodies targeting this loop trace native pronociceptin in hypothalamic perikarya, spinal dorsal horn, and adrenal medulla, delivering crisp cytoplasmic granules and single-band clarity on immunoblots with no cross-reaction to proenkephalin or prodynorphin.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.