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Mouse Anti-Rat 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for rat 3-hydroxy-3-methylglutaryl coenzyme A reductase. It is purified by protein A and protein G. It can be applied to WB, IHC, ICC and IP assays of rat 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Specifications
Target Information
Rat 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) is a key enzyme in the mevalonate pathway, responsible for catalyzing the conversion of HMG-CoA to mevalonate. This reaction is a rate-limiting step in cholesterol biosynthesis. HMGCR is expressed in various tissues, particularly in the liver, where it plays a crucial role in maintaining cholesterol homeostasis. Its activity is tightly regulated by feedback mechanisms involving cholesterol levels. HMGCR is an important target for studying lipid metabolism and developing cholesterol-lowering therapies in rat models.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Liscum, L., et al. "Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its mRNA in rat liver as studied with a monoclonal antibody and a cDNA probe." Journal of Biological Chemistry 258.13 (1983): 8450-8455. https://doi.org/10.1016/S0021-9258(20)82085-7