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Rabbit Anti-Mouse Nucleobindin 2 (NUCB2) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse nucleobindin 2. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse nucleobindin 2.
Specifications
Target Information
Mouse nucleobindin 2 (NUCB2) is a 53 kDa Ca²⁺-binding protein whose N-terminal DNA-like helix and two EF-hands form a Golgi-associated reservoir, cleaved to release nesfatin-1, an anorexigenic peptide. A solvent-exposed 15-aa "KVE" loop (aa 145-159) linking the second EF-hand and the leucine zipper folds into a β-hairpin unique among mouse nucleobindins, presenting a conformational epitope preserved after secretion and fixation. Affinity-purified antibodies targeting this loop trace native NUCB2 in hypothalamic neurons, pancreatic β-cells, and gastric endocrine cells, delivering crisp perinuclear and extracellular puncta with single-band clarity on immunoblots and no cross-reaction to NUCB1.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.