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Rabbit Anti-Mouse IL2 Inducible T-Cell Kinase (ITK) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse IL2 inducible T-cell kinase. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse IL2 inducible T-cell kinase.
Specifications
Target Information
Mouse IL-2-inducible T-cell kinase (ITK) is a cytoplasmic Tec-family tyrosine kinase essential for T-cell receptor signaling. Triggered by TCR engagement, ITK phosphorylates and activates PLC-γ1, leading to calcium influx, PKC activation, and transcription factor induction. Expressed in Th2, Th17, and iNKT cells, ITK modulates cytokine production, proliferation, and differentiation. Loss of ITK skews immunity toward Th1 responses and impairs allergic inflammation. As a critical node in T-cell activation, ITK is an important target for studies of adaptive immunity, autoimmunity, and kinase-directed therapeutics.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.