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Mouse Perforin 1 (PRF1) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Perforin 1 (PRF1) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse PRF1 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Profilin-1 interacts with actin monomers and plays a crucial role in organizing the actin cytoskeleton. It prevents actin polymerization at high concentrations but promotes it at low levels. In mouse breast cancer cells, Profilin-1 has a dual function: it aids tumor growth by enhancing cell proliferation and survival, and it also modulates tumor suppressor activity through its nuclear localization and phosphorylation at Ser-137. This phosphorylation at Ser-137 disrupts Profilin-1's interaction with its PLP site, lifting the inhibition on cell cycle arrest and increasing sensitivity to apoptosis, thus offering a potential target for cancer treatment.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.