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Rabbit Anti-Rat Period Circadian Protein 2 (PER2) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat period circadian protein 2. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of rat period circadian protein 2.
Specifications
Target Information
Rat period circadian protein 2 (PER2) is a 125 kDa nucleocytoplasmic clock scaffold whose N-terminal PAS-A/B domains clasp CRY1 while its C-terminal CK1ε-binding pocket sets the pace of phosphorylation-driven degradation. A unique 40-residue "hypersensitive loop" (aa 700-740) emerges only in the non-phosphorylated, transcriptionally active conformation, offering a selective epitope absent from paralogs PER1 and PER3. Antibodies raised against this loop detect native PER2 in suprachiasmatic nucleus, liver sinusoids, and cultured fibroblasts, delivering crisp nuclear/cytoplasmic oscillations with single-band specificity on immunoblots and no cross-reactivity to phosphorylated or ubiquitinated forms.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.