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Rabbit Anti-Rat Cytochrome P450 27B1 (CYP27B1) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat cytochrome P450 27B1. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of rat cytochrome P450 27B1.
Specifications
Target Information
Rat cytochrome P450 27B1 is a 56 kDa inner-mitochondrial enzyme whose heme-thiolate core converts 25-hydroxyvitamin D to the active 1,25-dihydroxy form, steering calcium and phosphate homeostasis. A solvent-exposed 15-aa "KVE" loop (aa 220-234) between helices F and G folds into a β-hairpin unique among rat P450s, presenting a conformational epitope preserved after paraformaldehyde fixation. Affinity-purified antibodies targeting this loop trace native CYP27B1 in renal proximal tubules, placental labyrinth, and osteoblastic layers, delivering crisp mitochondrial reticula and single-band clarity on immunoblots with no cross-reaction to CYP24A1 or CYP27A1.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.