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Rabbit Anti-Mouse Interleukin 33 (IL33) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse interleukin 33. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse interleukin 33.
Specifications
Target Information
Mouse interleukin 33 (IL-33) is a 30-kDa alarmin cytokine predominantly expressed in mouse epithelial cells (lung, gut, skin) and stromal cells. It is released upon tissue damage or inflammation, binding to its receptor ST2 (with IL-1RAcP co-receptor) on mast cells, Th2 cells, and regulatory T cells. This activates downstream NF-κB and MAPK signaling, driving production of Th2 cytokines (IL-4, IL-5, IL-13) and modulating allergic, inflammatory, and tissue repair responses. Critical for murine mucosal immunity and tissue homeostasis, its dysregulation associates with asthma, allergic rhinitis, and autoimmune diseases. As a key mediator of type 2 immunity and tissue damage responses, mouse IL-33 is a critical target for studying inflammatory pathologies and immunotherapeutic development.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.