Mouse Wingless Type MMTV Integration Site Family, Member 3A (WNT3A) ELISA Kit-Sandwich

Protein Wnt-3a serves as a ligand for the frizzled family of seven-transmembrane receptors, playing a crucial role in the canonical Wnt signaling pathway. This pathway leads to the activation of transcription factors belonging to the TCF/LEF family. Wnt-3a is essential for proper embryonic mesoderm development and the formation of caudal somites. Additionally, it enhances antioxidant metabolism by regulating the stability of NRF2 (nuclear factor E2-related factor 2). In mouse hepatocytes, Wnt-3a stabilizes NRF2, preventing its phosphorylation and subsequent degradation by GSK-3β, which results in increased expression of NRF2 and its downstream antioxidant enzymes, such as HO-1 and NQO1. This regulation occurs independently of the classic β-catenin signaling pathway and is mediated through the Axin1/NRF2 complex.