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Mouse Podocin (PDCN) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Podocin (PDCN) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse PDCN in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Podocin is essential for regulating glomerular permeability, likely serving as a connector between the plasma membrane and the cytoskeleton. This critical protein is located in the slit diaphragm of glomerular podocytes and is vital for maintaining the glomerular filtration barrier and preventing nephropathy. A deficiency in Podocin (as seen in Nphs2−/− mice) results in severe renal conditions, including proteinuria, tubulopathy, and renal failure. Furthermore, reduced or absent Podocin expression levels cause the disintegration of the slit diaphragm, leading to podocyte apoptosis and dysfunction of the glomerular filtration barrier.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Hirose, Tomonori et al. "An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms." PloS one vol. 4,1 (2009): e4194.