Mouse Creatine Kinase B-type (CKB) ELISA Kit-Sandwich

Creatine kinase B-type facilitates the reversible transfer of phosphate between ATP and different phosphogens, such as creatine phosphate. This enzyme and its isoforms are vital in energy transfer within tissues that experience significant and variable energy requirements, like skeletal muscle, the heart, brain, and sperm cells (likely). It serves as a crucial regulator in adaptive thermogenesis within the futile creatine cycle, targeting the mitochondria in thermogenic fat cells to mediate the phosphorylation of creatine. This initiates a cycle of creatine phosphorylation and dephosphorylation. In mice, the roles of Creatine Kinase B-type are particularly evident in maintaining energy balance in the brain, regulating neuronal axon transport, contributing to neural plasticity and synaptic development, and possibly influencing mitochondrial transfer and energy metabolism. CK-B is essential for sustaining cellular energy equilibrium, particularly in the brain. Research indicates that mice deficient in CK-B (CK-B-/-) do not show obvious anatomical changes in the brain but do exhibit significantly lower levels of ATP and creatine phosphate (PCr), underscoring CK-B's critical role in the brain's energy supply.