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Mouse Chromodomain Helicase DNA Binding Protein 4 (CHD4) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Chromodomain Helicase DNA Binding Protein 4 (CHD4) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse CHD4 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Chromodomain-helicase-DNA-binding protein 4 (CHD4) is an ATP-dependent helicase that binds to and distorts nucleosomal DNA. It is a component of the histone deacetylase NuRD complex, which is involved in chromatin remodeling. CHD4 plays significant biological roles in mice and other mammals, particularly in chromatin remodeling, gene expression regulation, DNA damage repair, and cancer development. It regulates nucleosome loading and dynamic chromatin remodeling by interacting with chromatin-associated proteins such as BRIT1 and p300. For instance, the interaction between CHD4 and BRIT1 is crucial for the chromatin localization of BRIT1. Defects in BRIT1 can impair the cell's ability to repair DNA damage, thereby increasing cancer risk.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.