Recombinant Mouse Glutathione S-Transferase theta-1 (Gstt1)

Mouse Glutathione S-Transferase theta-1 (Gstt1) is a member of the glutathione S-transferase (GST) superfamily, which catalyzes the conjugation of reduced glutathione to electrophilic and hydrophobic compounds. It plays a critical role in detoxification processes, protecting cells from oxidative stress and xenobiotics. Gstt1 is implicated in cancer progression, particularly in metastasis, where it promotes tumor cell survival and dissemination by modifying fibronectin in the metastatic microenvironment. In mouse models, Gstt1 is essential for reducing cisplatin-induced ototoxicity and protecting against colitis through goblet cell differentiation. Gstt1 is also associated with diseases like chronic obstructive pulmonary disease (COPD) and acute respiratory distress syndrome (ARDS). Its expression and activity make it a potential therapeutic target in conditions linked to oxidative stress and cancer.