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Recombinant Mouse Thrombospondin-1 (Thbs1), N-His
Product Overview
BioVenic's Recombinant Mouse Thrombospondin-1 (Thbs1), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 23.1 kDa. The purity is> 90%.
Specifications
Target Information
Mouse Thrombospondin-1 (Thbs1) is a multifunctional glycoprotein involved in tissue remodeling, immune regulation, and tumor progression. It is highly expressed in tumor microenvironments, where it promotes tumor invasion and metastasis while suppressing immune responses. Thbs1 modulates the activity of immune cells such as T cells and macrophages, creating an immunosuppressive environment that favors tumor growth. In mouse models, Thbs1 knockout has been shown to inhibit tumor metastasis and improve survival by enhancing immune cell infiltration. Additionally, Thbs1 is implicated in autoimmune diseases like Sjögren's syndrome, where its absence exacerbates inflammation and immune dysregulation. Thbs1 serves as a promising therapeutic target for cancer and immune-related disorders.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in deionized sterile water to a concentration of 0.1-0.5 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.