Recombinant Mouse Folate Receptor Alpha (FOLR1), C-His

Mouse Folate Receptor Alpha, or FOLR1, is a receptor expressed on cell surfaces, involved in folate uptake and metabolism. In mouse models, FOLR1 is used to study its roles in embryonic development and disease therapy. FOLR1 mediates the transport of folate into cells, which is essential for DNA synthesis, repair, and methylation. During embryogenesis, FOLR1 expression is critical for the proper development of the nervous system and other organs. In cancer research, FOLR1 has been targeted for drug delivery, as many cancer cells overexpress this receptor to meet their increased demand for folate. Additionally, FOLR1 is involved in the pathogenesis of certain neurological disorders, where its dysfunction can lead to impaired folate metabolism and neurodevelopmental abnormalities. Understanding the biology of FOLR1 has implications for developing novel therapeutic strategies for folate-related disorders and for improving the targeting of anticancer therapies.