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Rabbit Anti-Rat Thyroid Stimulating Hormone Receptor (TSHR) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat thyroid stimulating hormone receptor. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of rat thyroid stimulating hormone receptor.
Specifications
Target Information
Rat thyroid stimulating hormone receptor (TSHR) is a 84-kDa G protein-coupled receptor (GPCR) exclusively expressed in rat thyroid follicular cells. It binds thyroid stimulating hormone (TSH), activating cAMP and phosphatidylinositol signaling pathways to regulate thyroid hormone (T3/T4) synthesis, follicular cell proliferation, and iodine uptake. Critical for maintaining systemic metabolic homeostasis, growth, and thermoregulation in rats, it integrates hypothalamic-pituitary-thyroid axis signaling. Dysregulated activation or mutations associate with hyperthyroidism (Graves' disease), hypothyroidism, and thyroid tumors in rat models. As a central mediator of thyroid function and metabolic regulation, rat TSHR is a critical target for studying thyroid pathobiology and developing therapeutics for thyroid disorders.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.