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Rabbit Anti-Mouse Tryptophanyl tRNA Synthetase (WARS) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse tryptophanyl tRNA synthetase. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse tryptophanyl tRNA synthetase.
Specifications
Target Information
Mouse tryptophanyl-tRNA synthetase (WARS1) is a 53 kDa class-I enzyme whose Rossmann fold grips ATP and tryptophan, while an appended KMSKS loop seals the active site during aminoacylation. A solvent-exposed 14-residue "GNE" loop (aa 152-160) within the L-domain exhibits a mouse-specific glycine insertion, presenting a conformational epitope preserved in both cytoplasmic and secreted fragments. Affinity-purified antibodies targeting this loop detect native WARS1 in liver cytosol, brain synaptosomes, and activated macrophages, yielding crisp cytoplasmic puncta and single-band clarity on immunoblots with no cross-reaction to tyrosyl- or leucyl-tRNA synthetase.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.