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Rabbit Anti-Mouse Lysosomal Associated Membrane Protein 2 (LAMP2) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse lysosomal associated membrane protein 2. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse lysosomal associated membrane protein 2.
Specifications
Target Information
Mouse Lysosomal-Associated Membrane Protein 2 (LAMP-2) is a heavily glycosylated, type I trans-membrane protein that coats the inner leaflet of lysosomes and late endosomes, protecting the membrane from proteolytic attack while maintaining acidic hydrolase compartmentalization. Its large lumenal domain binds cholesterol and participates in chaperone-mediated autophagy by directly recognizing KFERQ-motif cytosolic proteins. Constitutive yet inducible expression in liver, kidney, and heart makes LAMP-2 a reliable lysosomal marker. Antibodies to LAMP-2 enable precise visualization of lysosomal compartments and quantitative assessment of autophagic flux in mouse development, metabolic, and neurodegeneration models without cross-reactivity to LAMP-1 or other membrane proteins.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.