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Rabbit Anti-Mouse NADPH Oxidase 4 (NOX4) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse NADPH oxidase 4. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse NADPH oxidase 4.
Specifications
Target Information
Mouse NADPH oxidase 4 (NOX4) is a 65-kDa transmembrane enzyme predominantly expressed in mouse vascular endothelial cells, fibroblasts, and epithelial tissues (lung, kidney, liver). It catalyzes reactive oxygen species (ROS) production-primarily hydrogen peroxide-using NADPH as an electron donor. Unlike other NOX isoforms, it functions constitutively, regulating physiological processes including cell differentiation, angiogenesis, and tissue repair. ROS generated by NOX4 also modulates redox signaling and gene expression. Dysregulated activity links to oxidative stress-related pathologies (fibrosis, cardiovascular diseases, chronic inflammation) in mice. As a tissue-specific ROS producer and redox signaling mediator, mouse NOX4 is a critical target for studying oxidative biology, fibrotic disorders, and cardiovascular pathologies.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.