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Rabbit Anti-Mouse Lamin A/C (LMNA) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse lamin A/C. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse lamin A/C.
Specifications
Target Information
Mouse Lamin A/C is a type V intermediate filament protein that forms a meshwork beneath the inner nuclear membrane, providing structural support to the nucleus and organizing chromatin. It regulates DNA replication, transcription, and nuclear shape, while interacting with transcription factors and signaling proteins. Lamin A/C is expressed in most differentiated cells, with highest levels in heart, skeletal muscle, and adipose tissue. Mutations or abnormal processing disrupt nuclear integrity, leading to mechanical stress and altered gene expression. As a key determinant of nuclear architecture and mechanotransduction, Lamin A/C is an important target for studies of aging, muscular dystrophies, and progeria syndromes.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.