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Mouse Urocortin 2 (UCN2) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Urocortin 2 (UCN2) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse UCN2 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Urocortin-2 reduces food intake, delays gastric emptying, and decreases heat-induced edema, potentially acting as an endogenous ligand to maintain homeostasis following stress. In mouse hearts, Urocortin-2 exhibits significant positive inotropic and diastolic effects primarily through the activation of the CRF receptor 2 (CRFR2) signaling pathway. It enhances intracellular calcium ion concentration (Ca²⁺) in cardiomyocytes by stimulating the cAMP/PKA and Ca²⁺/CaMK2 signaling pathways, thereby improving myocardial contractility and diastolic capacity. Additionally, Urocortin-2 enhances cardiac function in mice with heart failure by reducing left ventricular pressure and increasing cardiac output, highlighting its potential therapeutic value for cardiovascular diseases.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.