This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Mouse Protamine 2 (PRM2) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Protamine 2 (PRM2) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse PRM2 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Protamine-2 (Prm2) in mice is a specialized protamine that plays a critical role in sperm maturation. It is essential for several processes, including chromatin compaction, DNA protection, antioxidative stress defense, and maintaining sperm morphology and function. The absence of Prm2 diminishes the antioxidant capacity of sperm, leading to the downregulation of key antioxidant enzymes such as SOD1 and PRDX5, and triggering a cascade of oxidative stress-related damage. Protamine-2 is a small, arginine-rich protein that binds to DNA, compacting sperm chromatin to protect it from external damage, including DNA degradation and oxidative stress.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Schneider, Simon et al. "Protamine-2 Deficiency Initiates a Reactive Oxygen Species (ROS)-Mediated Destruction Cascade during Epididymal Sperm Maturation in Mice." Cells/ vol. 9,8 1789. 27 Jul. 2020.