Mouse Macrophage Inflammatory Protein 3 Alpha (MIP3a) ELISA Kit-Sandwich

C-C motif chemokine 20, also known as macrophage inflammatory protein 3 alpha, serves as a ligand for the C-C chemokine receptor CCR6. By binding to and activating CCR6, it triggers a potent chemotactic response and mobilizes intracellular calcium ions. The CCL20-CCR6 ligand-receptor pair is essential for the chemotaxis of dendritic cells (DC), effector/memory T-cells, and B-cells, playing a crucial role at skin and mucosal surfaces in both homeostatic and inflammatory conditions, as well as in pathological conditions like cancer and autoimmune diseases. In mice, CCL20 functions in immune regulation, inflammatory responses, tumor progression, and liver fibrosis. It recruits specific immune cells, such as neutrophils and Th17 cells, by binding to the CCR6 receptor, thus playing a key role in various pathological processes.