Mouse Kallikrein 3 (KLK3) ELISA Kit-Sandwich

Studies in mice have demonstrated that Kallikrein 3 is vital in various physiological and pathological processes, including immune-mediated nephritis, cardiovascular function, neuroprotection, hemostasis, thrombosis, tumors, and inflammation. Members of the kallikrein gene family, including KlK3, play a significant role in immune-mediated nephritis, such as in conditions like anti-GBM antibody-induced nephritis and idiopathic membranous nephropathy. As a tissue kallikrein (TK), Kallikrein 3 is crucial for cardiovascular function. Mice deficient in TK exhibit abnormal cardiac structures, such as a thinning ventricular wall and reduced left ventricular mass, along with vascular dysfunction, such as impaired flow-mediated vasodilation. Additionally, Kallikrein 3 promotes neuroprotection following ischemic events through its kallikrein activity.