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Mouse Protein Disulfide Isomerase A4 (PDIA4) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Protein Disulfide Isomerase A4 (PDIA4) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse PDIA4 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Protein disulfide-isomerase A4 (Pdia4), also known as PDIA4, facilitates the rearrangement of disulfide bonds (-S-S-) in proteins. In mice, Pdia4 is intimately connected to the pathophysiology of pancreatic beta cells and the progression of diabetes. It is predominantly expressed in pancreatic beta cells, with expression levels significantly increasing under conditions of high nutritional load, such as a high-fat diet or excessive nutrient intake. Research indicates that the absence of Pdia4 (Pdia4−/−) can substantially mitigate the onset of diabetes. For instance, in the Leprdb/db mouse model, the incidence of diabetes in Pdia4−/− mice decreased by 58%, and both their survival rate and lifespan showed considerable improvement.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.