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Mouse Jun B Proto Oncogene (JUNB) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Jun B Proto Oncogene (JUNB) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse JUNB in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Transcription factor JunB plays a crucial role in regulating gene activity following the primary growth factor response. In mice, JunB has a variety of functions, and its absence can result in several issues, including embryonic lethality, immune deficiencies, disorders of the hematopoietic system, and tumorigenesis. As a member of the AP-1 family, JunB is vital for embryonic development in mice. A deficiency in JunB leads to embryonic lethal defects between E8.5 and E10.5, mainly characterized by abnormal placenta formation and impaired angiogenesis. These defects stem from dysregulated expression of proliferation-related genes, such as proliferin, MMP-9, and uPA, in trophoblast cells, along with the downregulation of angiogenic factors like Vegf-1.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Yoshitomi, Yasuo et al. "Emerging Role of AP-1 Transcription Factor JunB in Angiogenesis and Vascular Development." International journal of molecular sciences vol. 22,6 2804. 10 Mar. 2021.