Mouse Integrin Beta 2 (ITGb2) ELISA Kit-Sandwich

Integrin ITGAL/ITGB2 acts as a receptor for ICAM1, ICAM2, ICAM3, and ICAM4. It also serves as a receptor for the secreted form of the ubiquitin-like protein ISG15, with this interaction being mediated by ITGAL. Integrin beta-2 plays a critical role in leukocyte adhesion and the transmigration of leukocytes, including T-cells and neutrophils, and facilitates neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. In mice, a deficiency in β2 integrin results in symptoms similar to human leukocyte adhesion disorder (LAD), characterized by impaired leukocyte adhesion and migration, along with recurrent infections and inflammatory responses. Mice lacking β2 integrin exhibit insulin resistance when subjected to a high-fat diet, accompanied by a marked increase in inflammatory factors (such as IL-1β and TNFα) in skeletal muscle, potentially linked to diminished insulin signaling.