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Mouse Granzyme M (GZMM) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Granzyme M (GZMM) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse GZMM in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Granzyme M is a serine protease exclusively expressed in natural killer (NK) cell granules, playing a crucial role in inducing cell apoptosis. Studies have revealed that Granzyme M mediates cell death in a perforin-dependent manner by working synergistically with perforin, a mechanism distinct from the traditional Granzyme B-mediated apoptosis pathway. In endotoxin infection models, the absence of Granzyme M significantly decreases mice's sensitivity to endotoxins. This is evidenced by reduced levels of inflammatory factors such as IL-1α, IL-1β, TNF, and IFN-γ, as well as enhanced resistance to lethal endotoxin infection.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.