This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Mouse Granzyme B (GZMB) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Granzyme B (GZMB) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse GZMB in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
In cytotoxic T-cells and NK-cells, Granzyme B is a prevalent protease that induces caspase-independent pyroptosis when introduced into the target cell via the immunological synapse. In mice, Granzyme B facilitates the apoptosis of target cells by working in conjunction with perforin and plays a crucial role in immune defense and tumor immunity. Notably, mouse Granzyme B is 30 times less toxic than its human counterpart and can induce cell death without relying on the Bid protein. However, its toxicity can be restored by engineering its active site. Additionally, mouse Granzyme B exhibits greater specificity for certain substrates, such as pro-caspase-3.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.